Synthesis of some benzylidene thiosemicarbazide derivatives and evaluation of their cytotoxicity on U87, MCF-7, A549, 3T3 and HUVEC cell lines

Iron homeostasis is altered in tumours response to a perturbation the expression of iron-dependent proteins. Therefore, iron chelators make cancerous cells more vulnerable deficiency. Compounds having thiosemicarbazide scaffold with ability metal complex formation have potential act as anticancer. A series derivatives were designed, synthesized successfully and their cytotoxicity was then tested on some well laboratory normal model systems by using colorimetric assay based WST-1 reagent. According results, compounds showed high toxicity effect both healthy cell lines. The results assays U87 A549 lines survivability less than 50 % at all concentrations higher 10 ppm for compounds. MCF-7 line exhibited approximately same behaviour had 60 %. 3T3 compared HUVEC completely different against selectivity index also measured study it could be concluded that profile shows significant difference, indicating good anticancer these